Langlois DK et al. 2013; Pharmacokinetics and relative bioavailability of D-penicillamine in fasted and nonfasted dogs; J. Vet. Intern. Med. 27(5): 1071-6

Study Design: Dogs received D-penicillamine (12.5 mg/kg PO) fasted and with food in a randomized, crossover design to test the effect if food on the bioavailability.

Results: Coadministration of D-penicillamine with food significantly decreases plasma drug concentration. There were significant reductions in relative bioavailability and Cmax in fed dogs.

Conclusions: Decreased bioavailability can result in decreased copper chelation efficacy. Therefore administration of D-penicillamine with food cannot be categorically recommended.

AUC0-24h parameters of D-penicillamine in fasted and fed dogs