Study Design: Dogs received D-penicillamine (12.5 mg/kg PO) fasted and with food in a randomized, crossover design to test the effect if food on the bioavailability.
Results: Coadministration of D-penicillamine with food significantly decreases plasma drug concentration. There were significant reductions in relative bioavailability and Cmax in fed dogs.
Conclusions: Decreased bioavailability can result in decreased copper chelation efficacy. Therefore administration of D-penicillamine with food cannot be categorically recommended.
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