Study design: Beagle dogs received various doses of NanoDTPATM capsules to decorporate administered 241Americium (241Am). Efficacy of NanoDTPATM was compared to intravenously administered saline and Zn-DTPA.
Results: Both DTPA formulations increased urinary and fecal 241Am excretion 10-fold compared to saline treatment and liver content of 241Am was about eightfold decreased compared to control.
Conclusions: Oral NanoDTPATM capsules are comparable to intravenously administered Zn-DTPA in their efficacy to decorporate 241Am in a dose dependent manner.
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